Spouse for House

Season 1, Episode 11: Revenge of the Nerds

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Jessica runs into an old JC schoolmate, Nelson, who has become rich and successful and hasn't forgotten that Jessica broke his heart all these years ago. Meanwhile, John is talent scouted by an agent who tells him he could have been a bigger star if he had met him earlier. John and Jessica wonder if their lives would have been much better had they never met and got married.